Pauli refers to K. H. Volkmann-Schluck's book "Nicolaus Cusanus - Die Philosophie im Ubergang von Mittelalter zur Neuzeit". Pauli comments on the translation of the Greek "hypostasis" into Latin "essential" or "substantic", and on the problematic of "overcoming the opposites" in Eestern/Western mysticism and philosophy.

Pauli mentions Kröner's illness, two long letters from Pauli to Kröner concerning Galileo and Nicholas of Cusa, and a lecture by Pauli on the neutrino.

Pauli discusses metaphysics, positivism, science and ethics, etc.

Pauli formulates propositions on positivism, determinism, neo-Darwinism, etc.

Concerns biology, evolution, and concepts relating to wholeness, and to the observer.

Pauli discusses, among other things, Schopenhauer, Greek and Buddhist philosoph, and the oppositions phenomenism-realism, consciousness-existence, observer-observed object, etc.

Pauli encloses a copy of the manuscript of his lecture in Mainz, and asks for comments.